There is lots of excitement in the medical community about using probiotics to treat all sorts of health conditions. One probiotic (beneficial bacteria) that has been tested in a number of studies with positive results is Lactobacillus sakei (L. sakei), which is also the bacteria in Lanto Sinus. Lactobacillus sakei is also known as Latilactobacillus sakei.

Researchers have been having positive results with L. sakei for a number of different health conditions, including sinusitis, atopic dermatitis, colitis, COVID, osteoarthritis, weight reduction, lowering cholesterol levels, teeth bleaching, and dry eye disease. The main reasons for the successful results are because L. sakei has anti-inflammatory properties, suppresses harmful bacteria, and has a positive effect on gut microbes.

There are different strains of L. sakei throughout the world, but the different strains have slightly different effects. Some of the studies used the strain found in Lanto Sinus (L. sakei Probio65) because it is a powerful strain, with many positive properties. It is especially effective against a variety of species of harmful bacteria that commonly cause problems, including Staphylococcus aureus (a big problem in sinusitis).

Studies using the L. sakei proBio65 strain (found in Lanto Sinus)

The L. sakei strain used in Lanto Sinus is being researched for a variety of health conditions, including sinusitis.

There has been one completed sinusitis study using the Lanto Sinus probiotic, and there are several other sinusitis studies using Lanto Sinus currently ongoing. The completed sinusitis study (in 2023) was in a group of difficult to treat chronic sinusitis patients, who had all undergone multiple sinus surgeries. In the study they had been using Lanto Sinus with these patients, with very good results.

Early studies (in 2005 and 2008) using L. sakei proBio65 found that it successfully treated atopic dermatitis in both dogs and mice.

In a more recent study (in 2021), the L. sakei proBio65 strain was found to be an effective atopic dermatitis treatment in children and adolescents (aged 3 to 18 years). In this study, both alive and dead cells of L. sakei proBio65 were taken orally (by mouth) for 12 weeks. They found an improvement of the atopic dermatitis in those who received either dead or alive cells of L. sakei, but not in the group that received a placebo.

L. sakei proBio65 was found to be anti-inflammatory in mice with colitis, thus a possible treatment. A 2022 study (done in human cells in a lab) found that it had anti-Covid infection properties – that it inhibited the virus and reduced its harmfulness.

Other medical studies using L. sakei

Other studies have used different L. sakei strains, which have been derived from a variety of plant sources, such as kale, broccoli, green tripe, and kimchi. A variety of health conditions have been studied.

Several studies reported that L. sakei, when taken as a dietary supplement, helped as a treatment for osteoarthritis. A well-done recent study randomly assigned people with chronic osteoarthritis knee pain to either a placebo or treatment group. The group taking L. sakei (10 billion CFU) daily for 12 weeks had reduced osteoarthritis pain, reduced stiffness, reduced inflammation, and it stopped cartilage degradation.  

Weight reduction has been a popular research topic in both humans and rodents (mice and rats). Several studies found that ingesting L. sakei daily resulted in weight loss and reduced body fat in adults. Interestingly, the studies also found that chronic inflammation markers went down after ingesting L. sakei for a few weeks – thus, it lowered chronic inflammation.

An interesting recent (2025) study found that L. sakei bleached black tea-stained artificial teeth better than hydrogen peroxide within 1 week of use. It also was protective against dental caries (cavities), it inhibited harmful bacteria (e.g., S. mutans), and had protective effects against periodontal tissue damage. Based on the findings, the researchers thought that L. sakei should be integrated into dental care.

Another well-done study (2023) found that L. sakei in eye drops significantly improved the signs and symptoms of dry eyes (when compared to placebo eye drops), but taking L. sakei in capsule form (live probiotic) by mouth had no effect. The L. sakei in the eye drops was not alive, yet it was effective in reducing inflammation in the eye.

Several studies have focused on colitis and other gut issues, and found that L. sakei reduces inflammation. One mouse study found that both live bacteria and inactivated (dead) cells of L. sakei reduced the symptoms and inflammation of ulcerative colitis in the mice. Another study focused on gut and airway inflammation and found that L. sakei reduces inflammation in both areas, as well as modulating the immune system and altering microbiomes.

Conclusion: The probiotic L. sakei has the potential to be used as a treatment alone or along with traditional medical treatments for a variety of health conditions. Results from the studies already done indicate that the positive results are because L. sakei suppresses or dominates over harmful bacteria, and also because it reduces inflammation – it is anti-inflammatory.

While earlier studies used only live L. sakei bacteria, more recent studies have also tested dead or inactivated L. sakei bacteria – and found similar positive results. If dead bacteria is just as effective as live L. sakei, then this will be a big plus. Both transportation and storage would be much easier and cheaper.

Research using L. sakei is just beginning. It’s an exciting time!